RNA structure. Ribozyme evolution at the crossroads.

@article{Joyce2000RNASR,
  title={RNA structure. Ribozyme evolution at the crossroads.},
  author={Gerald F Joyce},
  journal={Science},
  year={2000},
  volume={289 5478},
  pages={401-2}
}
Molecules that have similar sequences usually adopt the same structures and have the same functions. In his Perspective, Joyce explains that this is not always the case. In a remarkable study (Schultes and Bartel), an RNA sequence has been designed that can adopt two different structures, each with a different catalytic function. Joyce details how this study sheds light on the evolution of enzymes.