RNA structure characterization from chemical mapping experiments

  title={RNA structure characterization from chemical mapping experiments},
  author={Sharon Aviran and Julius B. Lucks and Lior Pachter},
  journal={2011 49th Annual Allerton Conference on Communication, Control, and Computing (Allerton)},
  • S. Aviran, J. Lucks, L. Pachter
  • Published 24 June 2011
  • Biology
  • 2011 49th Annual Allerton Conference on Communication, Control, and Computing (Allerton)
Despite great interest in solving RNA secondary structures due to their impact on function, it remains an open problem to determine structure from sequence. [] Key Method Here we introduce a new model for inference of chemical modification experiments, whose formulation results in closed-form maximum likelihood estimates that can be easily applied to data. The model can be specialized to both SHAPE-CE and SHAPE-Seq, and therefore allows for a direct comparison of the two technologies. We then show that the…

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