RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1.

@article{Dikfidan2014RNASA,
  title={RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1.},
  author={Aytac Dikfidan and Bernhard Loll and Cathleen Zeymer and Iris Magler and Tim Clausen and Anton Meinhart},
  journal={Molecular cell},
  year={2014},
  volume={54 6},
  pages={975-86}
}
RNA-specific polynucleotide kinases of the Clp1 subfamily are key components of various RNA maturation pathways. However, the structural basis explaining their substrate specificity and the enzymatic mechanism is elusive. Here, we report crystal structures of Clp1 from Caenorhabditis elegans (ceClp1) in a number of nucleotide- and RNA-bound states along the reaction pathway. The combined structural and biochemical analysis of ceClp1 elucidates the RNA specificity and lets us derive a general… CONTINUE READING

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