RNA silencing in plants

  title={RNA silencing in plants},
  author={David C. Baulcombe},
There are at least three RNA silencing pathways for silencing specific genes in plants. In these pathways, silencing signals can be amplified and transmitted between cells, and may even be self-regulated by feedback mechanisms. Diverse biological roles of these pathways have been established, including defence against viruses, regulation of gene expression and the condensation of chromatin into heterochromatin. We are now in a good position to investigate the full extent of this functional… 
Gene silencing in plants: a diversity of pathways.
Gene Silencing in Plants
The term gene silencing refers to an epigenetic phenomenon, the heritable inactivation of gene expression that does not involve any changes to the deoxyribonucleic acid (DNA) sequence. While this
Role of silencing in plant-virus interactions
Better understanding of the molecular bases of the induction and the suppression of RNA silencing dramatically improved basic knowledge about intimate plant-virus interactions and also provide valuable tools to unravel the diversity, regulation and evolution of RNA-silencing pathways.
Non‐cell autonomous RNA silencing
Gene silencing in plants
The role of viral proteins and nucleic acids in silencing suppression and possible biotechnological applications of this mechanism are discussed.
Role of silencing suppressor proteins.
Better understanding of action of silencing suppressors at molecular level dramatically improved basic knowledge about the intimate plant-virus interactions and also provided valuable tools to unravel the diversity, regulation, and evolution of RNA-silencing pathways.
RNA silencing and antiviral defense in plants.
Silencing suppression by geminivirus proteins.
Systemic antiviral silencing in plants.


Systemic signalling in gene silencing
This work describes here the recent discovery that there is a systemic signal that can mediate gene silencing in plants and infer that the signal molecule is likely to be a nucleic acid.
Viral suppression of RNA silencing in plants.
The presumed mode of action of some silencing suppressors is examined, and their value as molecular probes of the RNA silencing mechanism is discussed, and the biotechnological applications of silencing suppression are considered.
A similarity between viral defense and gene silencing in plants.
It was found that nepovirus infection of nontransgenic plants induces a resistance mechanism that is similar to transgene-induced gene silencing.
A species of small antisense RNA in posttranscriptional gene silencing in plants.
The 25-nucleotide antisense RNA detected in transgene-induced PTGS is likely synthesized from an RNA template and may represent the specificity determinant of PTGS.
Induction and Suppression of RNA Silencing by an Animal Virus
It is shown that flock house virus (FHV) is both an initiator and a target of RNA silencing in Drosophila host cells and that FHV infection requires suppression of RNAsilencing by an FHv-encoded protein, B2.
Identification of Virus-Encoded MicroRNAs
The small RNA profile of cells infected by Epstein-Barr virus is recorded and it is shown that EBV expresses several microRNA (miRNA) genes, which are identified viral regulators of host and/or viral gene expression.
Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase
The cloning of qde-1, the first cellular component of the gene-silencing mechanism to be isolated, defines a new gene family conserved among different species including plants, animals and fungi, which is similar to an RNA-dependent RNA polymerase found in the tomato.
A biochemical framework for RNA silencing in plants.
This finding supports the view that plant miRNAs direct RNAi and that miRNA-specified mRNA destruction is important for proper plant development and endonuclease complexes guided by small RNAs are a common feature of RNA silencing in both animals and plants.