RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease.

@article{Solga2015RNAsequencingRO,
  title={RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease.},
  author={Anne C. Solga and Winnie W. Pong and Jason R. Walker and Todd N. Wylie and Vincent J. Magrini and Anthony J. Apicelli and Malachi Griffith and Obi L. Griffith and Shinichi Kohsaka and Gregory F Wu and David L. Brody and Elaine R. Mardis and David H Gutmann},
  journal={Glia},
  year={2015},
  volume={63 4},
  pages={531-548}
}
Expression profiling of distinct central nervous system (CNS) cell populations has been employed to facilitate disease classification and to provide insights into the molecular basis of brain pathology. One important cell type implicated in a wide variety of CNS disease states is the resident brain macrophage (microglia). In these studies, microglia are often isolated from dissociated brain tissue by flow sorting procedures [fluorescence-activated cell sorting (FACS)] or from postnatal glial… CONTINUE READING
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