RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

@article{Cnop2012RNASI,
  title={RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.},
  author={Miriam Cnop and Baroj Abdulkarim and Guy Bottu and Daniel Antonio da Cunha and Mariana Igoillo-Esteve and Mattiafrancesco Masini and Jean-Val{\'e}ry Turatsinze and Thasso Griebel and Olatz Villate and Izortze Santin and Marco Bugliani and Laurence Ladri{\`e}re and Lorella Marselli and Mark I. McCarthy and Piero Marchetti and Michael Sammeth and Decio L. Eizirik},
  journal={Diabetes},
  year={2012},
  volume={63 6},
  pages={
          1978-93
        }
}
Pancreatic β-cell dysfunction and death are central in the pathogenesis of type 2 diabetes (T2D). Saturated fatty acids cause β-cell failure and contribute to diabetes development in genetically predisposed individuals. Here we used RNA sequencing to map transcripts expressed in five palmitate-treated human islet preparations, observing 1,325 modified genes. Palmitate induced fatty acid metabolism and endoplasmic reticulum (ER) stress. Functional studies identified novel mediators of adaptive… CONTINUE READING
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