RNA sequencing: from tag-based profiling to resolving complete transcript structure

@inproceedings{Klerk2014RNASF,
  title={RNA sequencing: from tag-based profiling to resolving complete transcript structure},
  author={Eleonora de Klerk and Johan T den Dunnen and Peter A. C. ‘t Hoen},
  booktitle={Cellular and Molecular Life Sciences},
  year={2014}
}
Technological advances in the sequencing field support in-depth characterization of the transcriptome. Here, we review genome-wide RNA sequencing methods used to investigate specific aspects of gene expression and its regulation, from transcription to RNA processing and translation. We discuss tag-based methods for studying transcription, alternative initiation and polyadenylation events, shotgun methods for detection of alternative splicing, full-length RNA sequencing for the determination of… CONTINUE READING
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