RNA-seq reveals aurora kinase-driven mTOR pathway activation in patients with sarcomatoid metastatic renal cell carcinoma.

@article{Pal2015RNAseqRA,
  title={RNA-seq reveals aurora kinase-driven mTOR pathway activation in patients with sarcomatoid metastatic renal cell carcinoma.},
  author={Sumanta Kumar Pal and Miaoling He and Tommy Richard Sun-wing Tong and Huiqing Wu and Xueli Liu and Clayton Stephen Lau and Jin-Hui Wang and C. J. W. Warden and Xiwei Wu and Sabina Signoretti and Toni K Choueiri and Jose A Karam and Jeremy O Jones},
  journal={Molecular cancer research : MCR},
  year={2015},
  volume={13 1},
  pages={130-7}
}
UNLABELLED Sarcomatoid metastatic renal cell carcinoma (mRCC) is associated with a poor prognosis, and the biology of the disease has been inadequately characterized. RNA sequencing (RNA-seq) was performed on adjacent benign, clear cell, and sarcomatoid components from clinical specimens with sarcomatoid mRCC. M phase and cell-cycle pathways were enriched… CONTINUE READING