RNA-seq-based mapping and candidate identification of mutations from forward genetic screens.

@article{Miller2013RNAseqbasedMA,
  title={RNA-seq-based mapping and candidate identification of mutations from forward genetic screens.},
  author={Adam C Miller and Nikolaus Obholzer and Arish N. Shah and Sean G. Megason and Cecilia B Moens},
  journal={Genome research},
  year={2013},
  volume={23 4},
  pages={679-86}
}
Forward genetic screens have elucidated molecular pathways required for innumerable aspects of life; however, identifying the causal mutations from such screens has long been the bottleneck in the process, particularly in vertebrates. We have developed an RNA-seq-based approach that identifies both the region of the genome linked to a mutation and candidate lesions that may be causal for the phenotype of interest. We show that our method successfully identifies zebrafish mutations that cause… CONTINUE READING
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