RNA replication: required intermediates and the dissociation of template, product, and Q beta replicase.

Abstract

Replication complexes containing only one molecule of Q beta replicase and one strand of midivariant RNA (MDV-1 RNA) template were prepared by incubating the replicase with an excess of MDV-1 (-) RNA. In the presence of excess minus strands, these monoenzyme replication complexes were shown to synthesize essentially pure MDV-1 (+) RNA in both the first and… (More)

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Cite this paper

@article{Dobkin1979RNARR, title={RNA replication: required intermediates and the dissociation of template, product, and Q beta replicase.}, author={Carl Dobkin and Donald Mills and Fred Russell Kramer and Sol Spiegelman}, journal={Biochemistry}, year={1979}, volume={18 10}, pages={2038-44} }