RNA replication by Q beta replicase: a working model.

  title={RNA replication by Q beta replicase: a working model.},
  author={David Brown and Larry Gold},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 21},
Two classes of RNA ligands that bound to separate, high affinity nucleic acid binding sites on Q beta replicase were previously identified. RNA ligands to the two sites, referred to as site I and site II, were used to investigate the molecular mechanism of RNA replication employed by the four-subunit replicase. Replication inhibition by site I- and site II-specific ligands defined two subsets of replicatable RNAs. When provided with appropriate 3' ends, ligands to either site served as… CONTINUE READING

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