RNA recombination of coronaviruses: localization of neutralizing epitopes and neuropathogenic determinants on the carboxyl terminus of peplomers.

@article{Makino1987RNARO,
  title={RNA recombination of coronaviruses: localization of neutralizing epitopes and neuropathogenic determinants on the carboxyl terminus of peplomers.},
  author={Syuichi Makino and John O. Fleming and James G. Keck and Stephen A. Stohlman and Michael M C Lai},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 18},
  pages={
          6567-71
        }
}
Murine coronaviruses undergo RNA recombination at a very high frequency. We have obtained a series of recombinant viruses using neutralizing monoclonal antibodies in conjunction with temperature-sensitive markers. All of the recombinants obtained have a crossover within gene C, which encodes the peplomer protein of the virus. The genetic structure of these recombinants suggests that the antigenic regions recognized by these neutralizing monoclonal antibodies are localized on the carboxyl… CONTINUE READING
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