RNA recombination in vivo in the absence of viral replication.

@article{Gallei2004RNARI,
  title={RNA recombination in vivo in the absence of viral replication.},
  author={Andreas Gallei and Alexander Pankraz and H. -L. Thiel and Paul Becher},
  journal={Journal of virology},
  year={2004},
  volume={78 12},
  pages={6271-81}
}
To study fundamental aspects of RNA recombination, an in vivo RNA recombination system was established. This system allowed the efficient generation of recombinant cytopathogenic pestiviruses after transfection of synthetic, nonreplicatable, subgenomic transcripts in cells infected with a replicating noncytopathogenic virus. Studies addressing the interplay between RNA recombination and replication revealed that cotransfection of noninfected cells with various pairs of nonreplicatable RNA… CONTINUE READING
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