RNA pseudouridylation: new insights into an old modification.

  title={RNA pseudouridylation: new insights into an old modification.},
  author={Junhui Ge and Y Q Yu},
  journal={Trends in biochemical sciences},
  volume={38 4},
Pseudouridine is the most abundant post-transcriptionally modified nucleotide in various stable RNAs of all organisms. Pseudouridine is derived from uridine via base-specific isomerization, resulting in an extra hydrogen-bond donor that distinguishes it from other nucleotides. In eukaryotes, uridine-to-pseudouridine isomerization is catalyzed primarily by box H/ACA RNPs, ribonucleoproteins that act as pseudouridylases. When introduced into RNA, pseudouridine contributes significantly to RNA… CONTINUE READING