RNA pseudoknots: Translational frameshifting and readthrough on viral RNAs

  title={RNA pseudoknots: Translational frameshifting and readthrough on viral RNAs},
  author={Edwin B. Ten Dam and Cornelius W. A. Pleij and Leendert Bosch},
  journal={Virus Genes},
Ribosomal frameshifting on retroviral RNAs has been proposed to be mediated by slippage of two adjacent tRNAs into the — 1 direction at a specific heptanucleotide sequence. Here we report a computer-aided analysis of the structure around the established or putative frameshift sites in a number of retroviral, coronaviral, toroviral, and luteoviral RNAs and two dsRNA yeast viruses. In almost all cases a stable hairpin was predicted four to nine nucleotides downstream of the shifty heptanucleotide… CONTINUE READING
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