RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast

@inproceedings{Kim2010RNAPM,
  title={RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast},
  author={Tae Soo Kim and Chih Long Liu and Moran Yassour and John Holik and Nir Friedman and Stephen Buratowski and Oliver J Rando},
  booktitle={Genome Biology},
  year={2010}
}
The use of genome-wide RNA abundance profiling by microarrays and deep sequencing has spurred a revolution in our understanding of transcriptional control. However, changes in mRNA abundance reflect the combined effect of changes in RNA production, processing, and degradation, and thus, mRNA levels provide an occluded view of transcriptional regulation. To partially disentangle these issues, we carry out genome-wide RNA polymerase II (PolII) localization profiling in budding yeast in two… CONTINUE READING

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Studitsky VM: RNA polymerase complexes cooperate to relieve the nucleosomal barrier and evict histones

  • OI Kulaeva, FK Hsieh
  • Proc Natl Acad Sci USA
  • 2010
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