RNA polymerase is poised for activation across the genome

  title={RNA polymerase is poised for activation across the genome},
  author={Ginger W Muse and Daniel A. Gilchrist and Sergei Nechaev and Ruchir Shah and Joel S. Parker and Sherry F. Grissom and Julia Zeitlinger and Karen Adelman},
  journal={Nature Genetics},
Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA polymerase II (Pol II) to a promoter is necessary and sufficient for activation of genes. However, there are a few notable exceptions to this paradigm, including heat shock genes and several proto… CONTINUE READING
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