RNA polymerase II with open and closed trigger loops: active site dynamics and nucleic acid translocation.

@article{Feig2010RNAPI,
  title={RNA polymerase II with open and closed trigger loops: active site dynamics and nucleic acid translocation.},
  author={Michael Feig and Zachary F Burton},
  journal={Biophysical journal},
  year={2010},
  volume={99 8},
  pages={2577-86}
}
RNA polymerase II is the central eukaryotic enzyme in transcription from DNA to RNA. The dynamics of RNA polymerase II is described from molecular-dynamics simulations started from two crystal structures with open and closed trigger loop (TL) forms. Dynamic transitions between neutral and forward translocated states were observed, especially for the downstream DNA duplex. Dynamic rearrangements were also seen in the active site environment, including conformations in which the active site… CONTINUE READING

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Site-directed mutagenesis, purification and assay of Saccharomyces cerevisiae RNA polymerase II

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