RNA polymerase II transcription initiation: a structural view.

  title={RNA polymerase II transcription initiation: a structural view.},
  author={Dimitar B. Nikolov and Stephen K. Burley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 1},
In eukaryotes, RNA polymerase II transcribes messenger RNAs and several small nuclear RNAs. Like RNA polymerases I and III, polymerase II cannot act alone. Instead, general initiation factors [transcription factor (TF) IIB, TFIID, TFIIE, TFIIF, and TFIIH] assemble on promoter DNA with polymerase II, creating a large multiprotein-DNA complex that supports accurate initiation. Another group of accessory factors, transcriptional activators and coactivators, regulate the rate of RNA synthesis from… CONTINUE READING
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