RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells.

@article{Ponnusamy2009RNAPI,
  title={RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells.},
  author={Moorthy P. Ponnusamy and Shonali Deb and Parama Dey and Subhankar Chakraborty and Satyanarayana Rachagani and Shantibhusan Senapati and Surinder K Batra},
  journal={Stem cells},
  year={2009},
  volume={27 12},
  pages={3001-11}
}
Embryonic stem cells (ESCs) maintain self-renewal while ensuring a rapid response to differentiation signals, but the exact mechanism of this process remains unknown. PD2 is the human homolog of the RNA polymerase II-associated factor 1 (Paf1). The Paf1/PD2 is a member of the human PAF complex that consists of four other subunits, hCdc73, hLeo1, hCtr9, and hSki8, and is involved in the regulation of transcriptional elongation and further downstream events. Here, we show that Paf1/PD2 is… CONTINUE READING

From This Paper

Topics from this paper.
21 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…