RNA polymerase II and the integration of nuclear events.

@article{Hirose2000RNAPI,
  title={RNA polymerase II and the integration of nuclear events.},
  author={Yutaka Hirose and James L Manley},
  journal={Genes \& development},
  year={2000},
  volume={14 12},
  pages={
          1415-29
        }
}
The synthesis of a messenger RNA in the nucleus of a eukaryotic cell is an immensely complex undertaking. Each step in the pathway requires an enormous number of protein factors and identifying them and figuring out how they work has been a major goal of molecular biologists for the last two decades. Based on in vitro assays showing that each of the major steps, that is, transcription, capping, splicing, and polyadenylation, can be carried out in isolation, and because intuitively each of these… 

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