RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components.

@article{Gallagher2004RNAPI,
  title={RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components.},
  author={Jennifer E G Gallagher and David A Dunbar and Sander Granneman and Brianna M. Mitchell and Yvonne N. Osheim and A. L. Beyer and S J Baserga},
  journal={Genes & development},
  year={2004},
  volume={18 20},
  pages={2506-17}
}
Sequential events in macromolecular biosynthesis are often elegantly coordinated. The small ribosomal subunit (SSU) processome is a large ribonucleoprotein (RNP) required for processing of precursors to the small subunit RNA, the 18S, of the ribosome. We have found that a subcomplex of SSU processome proteins, the t-Utps, is also required for optimal rRNA transcription in vivo in the yeast Saccharomyces cerevisiae. The t-Utps are ribosomal chromatin (r-chromatin)-associated, and they exist in a… CONTINUE READING
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