RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma brucei.

@article{Gnzl2003RNAPI,
  title={RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma brucei.},
  author={Arthur G{\"u}nzl and Thomas Bruderer and Gabriele Laufer and Bernd Schimanski and L Tu and Hui-Min Chung and Pei-Tseng Lee and Mary Gwo-Shu Lee},
  journal={Eukaryotic cell},
  year={2003},
  volume={2 3},
  pages={542-51}
}
In eukaryotes, RNA polymerase (pol) I exclusively transcribes the large rRNA gene unit (rDNA) and mRNA is synthesized by RNA pol II. The African trypanosome, Trypanosoma brucei, represents an exception to this rule. In this organism, transcription of genes encoding the variant surface glycoprotein (VSG) and the procyclins is resistant to alpha-amanitin, indicating that it is mediated by RNA pol I, while other protein-coding genes are transcribed by RNA pol II. To obtain firm proof for this… CONTINUE READING

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