RNA oxidation and zinc in hepatic encephalopathy and hyperammonemia

  title={RNA oxidation and zinc in hepatic encephalopathy and hyperammonemia},
  author={Freimut Schliess and Boris G{\"o}rg and Dieter H{\"a}ussinger},
  journal={Metabolic Brain Disease},
Hepatic encephalopathy is a neuropsychiatric manifestation of acute and chronic liver failure. Ammonia plays a key role in the pathogenesis of hepatic encephalopathy by inducing astrocyte swelling and/or sensitizing astrocytes to swelling by a heterogeneous panel of precipitating factors and conditions. Whereas astrocyte swelling in acute liver failure contributes to a clinically overt brain edema, a low grade glial edema without clinically overt brain edema is observed in hepatic… CONTINUE READING
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