RNA nucleotide methylation

  title={RNA nucleotide methylation},
  author={Yuri Motorin and Mark Helm},
  journal={Wiley Interdisciplinary Reviews: RNA},
  • Y. Motorin, M. Helm
  • Published 1 September 2011
  • Biology
  • Wiley Interdisciplinary Reviews: RNA
Methylation of RNA occurs at a variety of atoms, nucleotides, sequences and tertiary structures. Strongly related to other posttranscriptional modifications, methylation of different RNA species includes tRNA, rRNA, mRNA, tmRNA, snRNA, snoRNA, miRNA, and viral RNA. Different catalytic strategies are employed for RNA methylation by a variety of RNA‐methyltransferases which fall into four superfamilies. This review outlines the different functions of methyl groups in RNA, including biophysical… 
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  • M. Helm
  • Biology
    Nucleic acids research
  • 2006
Function, genomic and structural evidence on cases of folding space alteration by post-transcriptional modifications in native RNA are reviewed and methylations and uridine isomerization are reviewed.
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The collective importance of the modified nucleosides in ribosome function has been demonstrated for a number of organisms, and further studies may reveal how the individual players regulate these functions through synergistic or cooperative effects.
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.
Results uncover a novel biological function of Dnmt2-mediated tRNA methylation, and suggest a role for DnMT2 enzymes during the biogenesis of tRNA-derived small RNAs.
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Methylation of Selenocysteine tRNA Governs Differential Expression of Mammalian Selenoproteins and Adenosine to Inosine RNA Editing in Animal Cells.