RNA nucleotide methylation

@article{Motorin2011RNANM,
  title={RNA nucleotide methylation},
  author={Yuri Motorin and Mark Helm},
  journal={Wiley Interdisciplinary Reviews: RNA},
  year={2011},
  volume={2}
}
  • Y. Motorin, M. Helm
  • Published 1 September 2011
  • Biology
  • Wiley Interdisciplinary Reviews: RNA
Methylation of RNA occurs at a variety of atoms, nucleotides, sequences and tertiary structures. Strongly related to other posttranscriptional modifications, methylation of different RNA species includes tRNA, rRNA, mRNA, tmRNA, snRNA, snoRNA, miRNA, and viral RNA. Different catalytic strategies are employed for RNA methylation by a variety of RNA‐methyltransferases which fall into four superfamilies. This review outlines the different functions of methyl groups in RNA, including biophysical… 
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324 Citations
Highly Influential Citations
10
Background Citations
136
Methods Citations
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324 Citations

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Citation Type

Site-specific RNA methylation by a methyltransferase ribozyme
TLDR
A methyltransferase ribozyme is reported that catalyses the site-specific installation of 1-methyladenosine in a substrate RNA, using O 6 -methylguanine as a small-molecule cofactor, providing insights into the catalytic abilities of RNA.
Radical SAM-Mediated Methylation of Ribosomal RNA.
Long non-coding RNAs as targets for cytosine methylation
TLDR
It is demonstrated for the first time that the two well-studied regulatory long non-coding RNAs HOTAIR and XIST are targets of site-specific cytosine methylation, and it is suggested that cytosin methylation may serve as a general strategy to regulate the function of longnon-c coding RNAs.
Existence of Diverse Modifications in Small-RNA Species Composed of 16-28 Nucleotides.
TLDR
This study demonstrates the existence of diverse modifications in small RNAs composed of 16-28 nt, which may promote in-depth understanding of the regulatory roles of noncoding RNAs.
m1A Post-Transcriptional Modification in tRNAs
TLDR
Two enzyme families responsible for formation of 1-methyladenosine (m1A) at nucleotide position 9 and 58 in tRNA are described with a focus on the tRNA binding, m1A mechanism, protein domain organisation and overall structures.
Chemistry enters nucleic acids biology: Enzymatic mechanisms of RNA modification
TLDR
An extended summary of the enzymatic mechanisms involved in formation of different methylated nucleotides in RNA, as well as pseudouridine residues, which are almost universally conserved in all living organisms are given.
Repair of methyl lesions in RNA by oxidative demethylation
TLDR
In this review, recent findings on RNA demethylases as well as biological functions and inhibitors will be discussed.
RNA nucleotide methylation: 2021 update.
TLDR
Since the last review about a decade ago, the field has witnessed the re-emergence of mRNA methylation as an important mechanism in gene regulation, and a prediction of upcoming trends is attempted.
Structural basis for eukaryotic mRNA modification.
Genome recoding by tRNA modifications
TLDR
This review highlights the prominent modifications in the tRNA anticodon loop and discusses the functional relevance of these modifications in protein translation and their emerging role in eukaryotic genome recoding during cellular adaptation and disease.
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