RNA molecules stimulate prion protein conversion

@article{Deleault2003RNAMS,
  title={RNA molecules stimulate prion protein conversion},
  author={Nathan R. Deleault and Ralf W. Lucassen and Surachai Supattapone},
  journal={Nature},
  year={2003},
  volume={425},
  pages={717-720}
}
Much evidence supports the hypothesis that the infectious agents of prion diseases are devoid of nucleic acid, and instead are composed of a specific infectious protein. This protein, PrPSc, seems to be generated by template-induced conformational change of a normally expressed glycoprotein, PrPC (ref. 2). Although numerous studies have established the conversion of PrPC to PrPSc as the central pathogenic event of prion disease, it is unknown whether cellular factors other than PrPC might be… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 269 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 162 extracted citations

Phosphorylation of prion protein at serine 43 induces prion protein conformational change.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 5 Excerpts
Method Support
Highly Influenced

Nucleic acid-mediated protein aggregation and assembly.

Advances in protein chemistry and structural biology • 2011
View 5 Excerpts
Highly Influenced

Plasminogen stimulates propagation of protease-resistant prion protein in vitro.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2010
View 4 Excerpts
Highly Influenced

Prion strain interactions are highly selective.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 3 Excerpts
Highly Influenced

270 Citations

01020'06'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 270 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 43 references