RNA molecules stimulate prion protein conversion

@article{Deleault2003RNAMS,
  title={RNA molecules stimulate prion protein conversion},
  author={Nathan R. Deleault and Ralf W. Lucassen and Surachai Supattapone},
  journal={Nature},
  year={2003},
  volume={425},
  pages={717-720}
}

• Nathan R. Deleault, Ralf W. Lucassen, Surachai Supattapone
• Published 2003 in Nature
• DOI:10.1038/nature01979

Much evidence supports the hypothesis that the infectious agents of prion diseases are devoid of nucleic acid, and instead are composed of a specific infectious protein. This protein, PrPSc, seems to be generated by template-induced conformational change of a normally expressed glycoprotein, PrPC (ref. 2). Although numerous studies have established the conversion of PrPC to PrPSc as the central pathogenic event of prion disease, it is unknown whether cellular factors other than PrPC might be… CONTINUE READING

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