RNA-methyltransferase TrmA is a dual-specific enzyme responsible for C5-methylation of uridine in both tmRNA and tRNA.

@article{RanaeiSiadat2013RNAmethyltransferaseTI,
  title={RNA-methyltransferase TrmA is a dual-specific enzyme responsible for C5-methylation of uridine in both tmRNA and tRNA.},
  author={Ehsan Ranaei-Siadat and C{\'e}line Fabret and Bili Seijo and F. Dardel and Henri Grosjean and Sylvie Nonin-Lecomte},
  journal={RNA biology},
  year={2013},
  volume={10 4},
  pages={572-8}
}
In bacteria, trans-translation rescues stalled ribosomes by the combined action of tmRNA (transfer-mRNA) and its associated protein SmpB. The tmRNA 5' and 3' ends fold into a tRNA-like domain (TLD), which shares structural and functional similarities with tRNAs. As in tRNAs, the UUC sequence of the T-arm of the TLD is post-transcriptionally modified to m (5)UψC. In tRNAs of gram-negative bacteria, formation of m (5)U is catalyzed by the SAM-dependent methyltransferase TrmA, while formation of m… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.