RNA-mediated response to heat shock in mammalian cells

@article{Shamovsky2006RNAmediatedRT,
  title={RNA-mediated response to heat shock in mammalian cells},
  author={Ilya Shamovsky and Maxim V. Ivannikov and Eugene S. Kandel and David Gershon and Evgeny Nudler},
  journal={Nature},
  year={2006},
  volume={440},
  pages={556-560}
}
The heat-shock transcription factor 1 (HSF1) has an important role in the heat-shock response in vertebrates by inducing the expression of heat-shock proteins (HSPs) and other cytoprotective proteins. HSF1 is present in unstressed cells in an inactive monomeric form and becomes activated by heat and other stress stimuli. HSF1 activation involves trimerization and acquisition of a site-specific DNA-binding activity, which is negatively regulated by interaction with certain HSPs. Here we show… 

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