RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle

@article{Spanggord2005RNAmediatedIB,
  title={RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle},
  author={Richard J Spanggord and Fai Siu and Ailong Ke and Jennifer A. Doudna},
  journal={Nature Structural &Molecular Biology},
  year={2005},
  volume={12},
  pages={1116-1122}
}
The signal recognition particle (SRP) targets nascent proteins to cellular membranes for insertion or secretion by recognizing polypeptides containing an N-terminal signal sequence as they emerge from the ribosome. GTP-dependent binding of SRP to its receptor protein leads to controlled release of the nascent chain into a membrane-spanning translocon pore. Here we show that the association of the SRP with its receptor triggers a marked conformational change in the complex, localizing the SRP… CONTINUE READING