RNA-mediated gene silencing of the RON receptor tyrosine kinase alters oncogenic phenotypes of human colorectal carcinoma cells

@article{Xu2004RNAmediatedGS,
  title={RNA-mediated gene silencing of the RON receptor tyrosine kinase alters oncogenic phenotypes of human colorectal carcinoma cells},
  author={Xiang-ming Xu and Da Wang and Qi Shen and Yi-qing Chen and Ming-Hai Wang},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={8464-8474}
}
Altered expression of receptor tyrosine kinases contributes to tumorigenic behaviors of epithelial cancers. In this study, the pathogenic roles of receptor tyrosine kinase RON (recepteur d'origine nantais) in regulating oncogenic phenotypes in colorectal epithelial cells were studied. Increased expression of RON and its variants resulted in colony formation and motile activities of colonic epithelial AA/C1 cells as evident in soft-agar and migration assays, respectively. These results suggest… CONTINUE READING
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