RNA mango aptamer-fluorophore: a bright, high-affinity complex for RNA labeling and tracking.

Abstract

Because RNA lacks strong intrinsic fluorescence, it has proven challenging to track RNA molecules in real time. To address this problem and to allow the purification of fluorescently tagged RNA complexes, we have selected a high affinity RNA aptamer called RNA Mango. This aptamer binds a series of thiazole orange (fluorophore) derivatives with nanomolar… (More)
DOI: 10.1021/cb500499x

Topics

7 Figures and Tables

Cite this paper

@article{Dolgosheina2014RNAMA, title={RNA mango aptamer-fluorophore: a bright, high-affinity complex for RNA labeling and tracking.}, author={Elena V Dolgosheina and Sunny C.Y. Jeng and S. Panchapakesan and Razvan Cojocaru and Patrick S. Chen and Peter Murray Wilson and Nancy Hawkins and Paul A. Wiggins and Peter J. Unrau}, journal={ACS chemical biology}, year={2014}, volume={9 10}, pages={2412-20} }