RNA interference targets arbovirus replication in Culicoides cells.

  title={RNA interference targets arbovirus replication in Culicoides cells.},
  author={Esther Schnettler and Maxime Ratinier and Mick Watson and Andrew E. Shaw and Melanie McFarlane and Mariana Varela and Richard M. Elliott and Massimo Palmarini and Alain Kohl},
  journal={Journal of virology},
  volume={87 5},
Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks, and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms. RNA interference (RNAi) is a sequence-specific RNA degradation mechanism that has been shown to play a major role in the antiviral response against arboviruses in mosquitoes. Culicoides midges are important vectors of arboviruses, known to transmit… CONTINUE READING
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