RNA interference targeting alpha8 integrin attenuates smooth muscle cell growth.

@article{Zargham2007RNAIT,
  title={RNA interference targeting alpha8 integrin attenuates smooth muscle cell growth.},
  author={Ramin Zargham and Brian R. Wamhoff and Ga{\'e}tan Thibault},
  journal={FEBS letters},
  year={2007},
  volume={581 5},
  pages={939-43}
}
alpha8 integrin gene silencing has been shown to result in the stress fibre disassembly. Stress fibres are required for cell adhesion to promote passage through cell cycle. Thus, we hypothesized that alpha8 integrin gene silencing might affect vascular smooth muscle cell (VSMC) growth. Short interference RNA (siRNA) targeting alpha8 integrin in rat VSMCs resulted in reduced DNA synthesis. Moreover, siRNA-alpha8 integrin prevented thrombin-induced proliferation. RhoA plays a critical role in… CONTINUE READING