RNA interference targeting E637K mutation rescues hERG channel currents and restores its kinetic properties.

Abstract

BACKGROUND Long QT syndrome (LQTS) is a monogenic proarrhythmic disorder that predisposes affected individuals to sudden death from tachyarrhythmia. As an inherited disease, LQTS cannot be completely cured by conventional treatment modalities. Individualized gene therapy is a promising therapeutic approach. OBJECTIVE The purpose of this study was to… (More)
DOI: 10.1016/j.hrthm.2012.09.124

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