RNA interference targeted to the conserved dimerization initiation site (DIS) of HIV-1 restricts virus escape mutation.

Abstract

Short hairpin RNAs (shRNA) targeting viral or cellular genes can effectively inhibit human immunodeficiency virus type 1 (HIV-1) replication. This inhibition, however, may induce mutations in the targeted gene, leading to rapid escape from the shRNA-induced inhibition. We generated a lymphoid cell line that stably expressed a 19-bp shRNA targeting a well… (More)
DOI: 10.1093/jb/mvp093

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@article{Sugiyama2009RNAIT, title={RNA interference targeted to the conserved dimerization initiation site (DIS) of HIV-1 restricts virus escape mutation.}, author={Ryuichi Sugiyama and Yuichiro Habu and Aki Ohnari and Naoko Miyano-Kurosaki and Hiroshi Takaku}, journal={Journal of biochemistry}, year={2009}, volume={146 4}, pages={481-9} }