RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival.

Abstract

Hepatocyte growth factor/scatter factor-Met signaling has been implicated in tumor growth, invasion, and metastasis. Suppression of this signaling pathway by targeting the Met protein tyrosine kinase may be an ideal strategy for suppressing malignant tumor growth. Using RNA interference technology and adenovirus vectors carrying small-interfering RNA… (More)

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@article{Shinomiya2004RNAIR, title={RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival.}, author={Nariyoshi Shinomiya and Chong Feng Gao and Qian Xie and Margaret Gustafson and David Waters and Yu-wen Zhang and George F. Vande Woude}, journal={Cancer research}, year={2004}, volume={64 21}, pages={7962-70} }