RNA interference of avian influenza virus H5N1 by inhibiting viral mRNA with siRNA expression plasmids.

@article{Zhou2008RNAIO,
  title={RNA interference of avian influenza virus H5N1 by inhibiting viral mRNA with siRNA expression plasmids.},
  author={Kai Zhou and Hongxuan He and Yanyun Wu and Mingxing Duan},
  journal={Journal of biotechnology},
  year={2008},
  volume={135 2},
  pages={140-4}
}
Avian influenza virus H5N1 causes widespread infection in the birds and human respiratory tract, but existing vaccines and drug therapy are of limited value. Here we show that small interfering RNAs (siRNAs) specific for conserved regions of the viral genome can potently inhibit influenza virus production in cell lines, embryonated chicken eggs and BALB/c mice. siRNA expression plasmid pBabe-Super was chosen in the study, which directed the synthesis of small interfering RNAs in cells. The… CONTINUE READING

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