RNA interference of HIV replication.

  title={RNA interference of HIV replication.},
  author={Miguel {\'A}ngel Mart{\'i}nez and Bonaventura Clotet and Jos{\'e} A. Est{\'e}},
  journal={Trends in immunology},
  volume={23 12},
Double-stranded RNA-mediated interference (RNAi) induces sequence-specific post-transcriptional gene silencing and has emerged as a powerful tool to silence gene expression in multiple organisms. In mammalian cells, duplexes of 21 nucleotide RNAs, known as short-interfering RNAs (siRNAs), efficiently inhibit gene expression. Recent research demonstrates the general use of siRNAs to specifically inhibit HIV-1 replication by targeting viral or cellular genes. Importantly, RNAi opens a new avenue… CONTINUE READING

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