RNA interference-mediated silencing of iASPP induces cell proliferation inhibition and G0/G1 cell cycle arrest in U251 human glioblastoma cells

@article{Li2010RNAIS,
  title={RNA interference-mediated silencing of iASPP induces cell proliferation inhibition and G0/G1 cell cycle arrest in U251 human glioblastoma cells},
  author={Guilin Li and Renzhi Wang and Jun Gao and Kan Deng and Junji Wei and Yanping Wei},
  journal={Molecular and Cellular Biochemistry},
  year={2010},
  volume={350},
  pages={193-200}
}
iASPP is an evolutionally conserved inhibitory member of the ASPP (apoptosis-stimulating protein of p53) protein family. Overexpression of iASPP was observed in several types of human tumors, however, its role in tumorigenesis has not been fully clarified. To investigate the role of iASPP in human glioblastoma multiforme (GMB) progression, the authors employed lentivirus-mediated shRNA to silence endogenous iASPP expression and elucidated iASPP function by analysis of viability, colony… CONTINUE READING

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