RNA interference-mediated control of hepatitis B virus and emergence of resistant mutant.

BACKGROUND & AIMS Present therapy for chronic hepatitis B attains control only in limited proportions. Small interfering RNA (siRNA) offers a new tool with potential therapeutic applications for hepatitis B virus (HBV). Given the importance of sequence identity in the effectiveness of siRNA and the heterogeneity of HBV sequences among different isolates, a… CONTINUE READING