RNA interference is required for normal centromere function infission yeast

@article{Volpe2004RNAII,
  title={RNA interference is required for normal centromere function infission yeast},
  author={Tom Volpe and Vera Schramke and Georgina L. Hamilton and Sharon A. White and Grace Teng and Robert A. Martienssen and Robin C. Allshire},
  journal={Chromosome Research},
  year={2004},
  volume={11},
  pages={137-146}
}
In plants, animals and fungi, active centromeres are associated with arrays of repetitive DNA sequences. The outer repeats at fission yeast (Schizosaccharomyces pombe) centromeres are heterochromatic and are required for the assembly of an active centromere. Components of the RNA interference (RNAi) machinery process transcripts derived from these repeats and mediate the formation of silent chromatin. A subfragment of the repeat (dg) is known to induce silencing of marker genes at euchromatic… Expand
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