RNA interference is an antiviral defence mechanism in Caenorhabditis elegans

@article{Wilkins2005RNAII,
  title={RNA interference is an antiviral defence mechanism in Caenorhabditis elegans},
  author={Courtney R Wilkins and Ryan Dishongh and Steve C. Moore and Michael A. Whitt and Marie Chow and Khaled Machaca},
  journal={Nature},
  year={2005},
  volume={436},
  pages={1044-1047}
}
RNA interference (RNAi) is an evolutionarily conserved sequence-specific post-transcriptional gene silencing mechanism that is well defined genetically in Caenorhabditis elegans. RNAi has been postulated to function as an adaptive antiviral immune mechanism in the worm, but there is no experimental evidence for this. Part of the limitation is that there are no known natural viral pathogens of C. elegans. Here we describe an infection model in C. elegans using the mammalian pathogen vesicular… CONTINUE READING