RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis.

@article{Blackburn2007RNAII,
  title={RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis.},
  author={Jessica S. Blackburn and C. Harker Rhodes and Charles I. Coon and Constance E. Brinckerhoff},
  journal={Cancer research},
  year={2007},
  volume={67 22},
  pages={10849-58}
}
Melanoma incidence is increasing worldwide, and metastatic melanoma is almost completely resistant to every known therapy. New approaches to treating melanoma are urgently needed, and a greater understanding of the biology of melanoma invasion and metastasis will aid in their creation. A high proportion of invasive melanomas have a constitutively active Raf/mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK/ERK) signaling cascade; however, the downstream effectors of… CONTINUE READING
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