RNA interference in J774 macrophages reveals a role for coronin 1 in mycobacterial trafficking but not in actin-dependent processes.

@article{Jayachandran2008RNAII,
  title={RNA interference in J774 macrophages reveals a role for coronin 1 in mycobacterial trafficking but not in actin-dependent processes.},
  author={Rajesh Jayachandran and John Gatfield and Jan Massner and Imke Albrecht and Bettina Zanolari and Jean Pieters},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 3},
  pages={
          1241-51
        }
}
Macrophages are crucial for innate immunity, apoptosis, and tissue remodeling, processes that rely on the capacity of macrophages to internalize and process cargo through phagocytosis. Coronin 1, a member of the WD repeat protein family of coronins specifically expressed in leukocytes, was originally identified as a molecule that is recruited to mycobacterial phagosomes and prevents the delivery of mycobacteria to lysosomes, allowing these to survive within phagosomes. However, a role for… CONTINUE READING