RNA interference-directed caveolin-1 knockdown sensitizes SN12CPM6 cells to doxorubicin-induced apoptosis and reduces lung metastasis

@article{Park2010RNAIC,
  title={RNA interference-directed caveolin-1 knockdown sensitizes SN12CPM6 cells to doxorubicin-induced apoptosis and reduces lung metastasis},
  author={Juwon Park and Eunkyung Cate Bae and Chansu Lee and Sung Soo Yoon and Yang Seok Chae and Kwang-Sung Ahn and Nam Hee Won},
  journal={Tumor Biology},
  year={2010},
  volume={31},
  pages={643-650}
}
Human renal cell carcinoma (HRCC) is characterized by a high level of resistance to all treatment modalities. Therefore, the investigation of global gene expression in HRCC might help understand its biologic behavior and develop treatment strategies. Using cDNA microarray analysis, we initially compared gene expression profiles between HRCCs and adjacent normal tissues, and found that 87 were up-regulated and 127 genes were down-regulated. Next, a subset of genes, twofold differentially… CONTINUE READING
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