RNA interference as an antiviral approach: targeting HIV-1.

  title={RNA interference as an antiviral approach: targeting HIV-1.},
  author={Ben Berkhout},
  journal={Current opinion in molecular therapeutics},
  volume={6 2},
  • Ben Berkhout
  • Published 2004 in Current opinion in molecular therapeutics
RNA interference (RNAi) is an evolutionary conserved gene-silencing mechanism in which 21- to 23-mer double-stranded short interfering RNA (siRNA) mediates the sequence-specific degradation of mRNA. The recent discovery that exogenously delivered siRNA can trigger RNAi in mammalian cells raises the possibility of using this technology as a therapeutic tool against pathogenic viruses. This review describes the antiviral RNAi field, which is barely two years-old, with an emphasis on recent… CONTINUE READING

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