RNA interference analyses suggest a transcript-specific regulatory role for mitochondrial RNA-binding proteins MRP1 and MRP2 in RNA editing and other RNA processing in Trypanosoma brucei.

@article{Vondrukov2005RNAIA,
  title={RNA interference analyses suggest a transcript-specific regulatory role for mitochondrial RNA-binding proteins MRP1 and MRP2 in RNA editing and other RNA processing in Trypanosoma brucei.},
  author={Eva Vondru{\vs}kov{\'a} and Janny van den Burg and Alena Z{\'i}kov{\'a} and Nancy Lewis Ernst and Kenneth Stuart and R. Benne and Julius Luke{\vs}},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 4},
  pages={2429-38}
}
Mitochondrial RNA-binding proteins MRP1 and MRP2 occur in a heteromeric complex that appears to play a role in U-insertion/deletion editing in trypanosomes. Reduction in the levels of MRP1 (gBP21) and/or MRP2 (gBP25) mRNA by RNA interference in procyclic Trypanosoma brucei resulted in severe growth inhibition. It also resulted in the loss of both proteins, even when only one of the MRP mRNAs was reduced, indicating a mutual dependence for stability. Elimination of the MRPs gave rise to… CONTINUE READING

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