RNA interference: potential therapeutic targets

@article{Jana2004RNAIP,
  title={RNA interference: potential therapeutic targets},
  author={Snehasis Jana and Chaitaly T. Chakraborty and Shivani Nandi and J. K. Deb},
  journal={Applied Microbiology and Biotechnology},
  year={2004},
  volume={65},
  pages={649-657}
}
One of the most exciting findings in recent years has been the discovery of RNA interference (RNAi). RNAi methodologies hold the promise to selectively inhibit gene expression in mammals. RNAi is an innate cellular process activated when a double-stranded RNA (dsRNA) molecule of greater than 19 duplex nucleotides enters the cell, causing the degradation of not only the invading dsRNA molecule, but also single-stranded (ssRNAs) RNAs of identical sequences, including endogenous mRNAs. The use of… 
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46 Citations
Background Citations
9
Methods Citations
2

46 Citations

Citation Type

Citation Type

Illuminating the Gateway of Gene Silencing: Perspective of RNA Interference Technology in Clinical Therapeutics
TLDR
The recent discoveries associated with the phenomenon of RNAi, expression of silencing molecules in mammals along with the vector systems used for disease therapeutics are highlighted.
In vivo delivery aspects of miRNA, shRNA and siRNA.
TLDR
The types of RNAi and their application in a variety of diseases using both local and systemic delivery approaches are described and it is sure that advancement in this direction will evolve a new landscape for treating a range of diseases.
Nonviral methods for siRNA delivery.
TLDR
This review provides an overview of the current delivery strategies for synthetic siRNA, focusing on the targeted, self-assembled nanoparticles which show potential to become a useful and efficient tool in cancer therapy.
Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2
The sense strand pre-cleaved RNA duplex mediates an efficient RNA interference with less off-target and immune response effects
TLDR
It is reported that RNA duplex with the sense strand pre-cleaved at the base between base 10 and 11 relative to the 5′ end of the antisense strand induced a target-specific RNA silencing effectively.
BARRIERS TO SUCCESSFUL DELIVERY OF SHORT INTERFERING RNA AFTER SYSTEMIC ADMINISTRATION
  • P. White
  • Biology
    Clinical and experimental pharmacology & physiology
  • 2008
TLDR
The present review considers the biological barriers that limit the movement of siRNA from vascular lumen to target cell cytoplasm and the strategies that have been used to overcome them.
Non-viral vectors for the mediation of RNAi.
Off-target possibility of efficient siRNA using String matching
  • S. Prameela, A. S. Jereesh
  • Biology
    2017 International Conference on Circuit ,Power and Computing Technologies (ICCPCT)
  • 2017
TLDR
This work uses string matching algorithm in GPU instead of BLAST to design an efficient exogenous siRNA and the original experimental value of Huesken data set is used to evaluate the current work.
Cationic lipids and polymers mediated vectors for delivery of siRNA.
Polymer siRNA conjugates synthesised by controlled radical polymerisation
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