RNA interference: potential therapeutic targets

@article{Jana2004RNAIP,
  title={RNA interference: potential therapeutic targets},
  author={S. Jana and C. Chakraborty and S. Nandi and J. K. Deb},
  journal={Applied Microbiology and Biotechnology},
  year={2004},
  volume={65},
  pages={649-657}
}
One of the most exciting findings in recent years has been the discovery of RNA interference (RNAi). RNAi methodologies hold the promise to selectively inhibit gene expression in mammals. RNAi is an innate cellular process activated when a double-stranded RNA (dsRNA) molecule of greater than 19 duplex nucleotides enters the cell, causing the degradation of not only the invading dsRNA molecule, but also single-stranded (ssRNAs) RNAs of identical sequences, including endogenous mRNAs. The use of… Expand
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