RNA interference: The molecular immune system

@article{Bagasra2004RNAIT,
  title={RNA interference: The molecular immune system},
  author={Omar Bagasra and Kiley R. Prilliman},
  journal={Journal of Molecular Histology},
  year={2004},
  volume={35},
  pages={545-553}
}
Introduction of double-stranded RNA (dsRNA) into cells expressing a homologous gene triggers RNA interference (RNAi), or RNA-based gene silencing (RBGS). The dsRNA degrades corresponding host mRNA into small interfering RNAs (siRNAs) by a protein complex containing Dicer. siRNAs in turn are incorporated into the RNA-induced silencing complex (RISC) that includes helicase, RecA, and exo- and endo-nucleases as well as other proteins. Following its assembly, the RISC guides the RNA degradation… Expand
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