RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans.

@article{Seo2016RNAHS,
  title={RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans.},
  author={Mihwa Seo and Sangsoon Park and Hong Gil Nam and Seung-Jae V Lee},
  journal={Cell cycle},
  year={2016},
  volume={15 14},
  pages={
          1821-9
        }
}
RNA helicases, which unwind RNAs, are essential for RNA metabolism and homeostasis. However, the roles of RNA helicases in specific physiological processes remain poorly understood. We recently reported that an RNA helicase, HEL-1, promotes long lifespan conferred by reduced insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) in Caenorhabditis elegans. We also showed that HEL-1 induces the expression of longevity genes by physically interacting with Forkhead box O (FOXO) transcription… CONTINUE READING
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